Genetics of type 1 diabetes

被引：60

作者：

Pugliese, A ^{[1
]}

机构：

[1] Univ Miami, Sch Med, Dept Med, Miami, FL 33152 USA

[2] Univ Miami, Sch Med, Dept Immunol, Miami, FL 33152 USA

[3] Univ Miami, Sch Med, Dept Microbiol, Miami, FL 33152 USA

[4] Univ Miami, Sch Med, Immunogenet Program, Diabet Res Inst, Miami, FL 33136 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2004年 / 33卷 / 01期

关键词：

D O I：

10.1016/S0889-8529(03)00082-3

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Type 1 diabetes (T1D) is a chronic condition of insulin deficiency resulting from the autoimmune destruction of pancreatic beta cells. Genetic factors influence both susceptibility to and resistance from T1D. These factors include inherited polymorphisms, epigenetic mechanisms regulating the expression of inherited alleles, and post-transcriptional regulatory mechanisms. This article reviews the current knowledge about the genetics of T1D and the plausible mechanisms of susceptibility and resistance.

引用

页码：1 / +

页数：17

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