Studying immunity to zoonotic diseases in the natural host - keeping it real

被引：71

作者：

Bean, Andrew G. D. ^{[1
]}

Baker, Michelle L. ^{[1
]}

Stewart, Cameron R. ^{[1
]}

Cowled, Christopher ^{[1
]}

Deffrasnes, Celine ^{[1
]}

Wang, Lin-Fa ^{[1
,2
]}

Lowenthal, John W. ^{[1
,3
]}

机构：

[1] CSIRO Biosecur Flagship, Australian Anim Hlth Lab, Geelong, Vic 3220, Australia

[2] Duke NUS Grad Med Sch, Program Emerging Infect Dis, Singapore 169857, Singapore

[3] Deakin Univ, Sch Med, Waurn Ponds, Vic 3216, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 12期

关键词：

INFLUENZA-A-VIRUS; ROSS RIVER VIRUS; H7N9; VIRUS; GENOME; GENE; RESPONSES; INTERFERENCE; MODELS; ORIGIN; MOUSE;

D O I：

10.1038/nri3551

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Zoonotic viruses that emerge from wildlife and domesticated animals pose a serious threat to human and animal health. In many instances, mouse models have improved our understanding of the human immune response to infection; however, when dealing with emerging zoonotic diseases, they may be of limited use. This is particularly the case when the model fails to reproduce the disease status that is seen in the natural reservoir, transmission species or human host. In this Review, we discuss how researchers are placing more emphasis on the study of the immune response to zoonotic infections in the natural reservoir hosts and spillover species. Such studies will not only lead to a greater understanding of how these infections induce variable disease and immune responses in distinct species but also offer important insights into the evolution of mammalian immune systems.

引用

页码：851 / 861

页数：11

共 78 条

[1]

[Anonymous], 2007, Clin Infect Dis

[2]

[Anonymous], OV EM CHAR AV INFL A

[3] Antiviral Immune Responses of Bats: A Review [J].

Baker, M. L. ;

Schountz, T. ;

Wang, L. -F. .

ZOONOSES AND PUBLIC HEALTH, 2013, 60 (01) :104-116

[4] Association of RIG-I with innate immunity of ducks to influenza [J].

Barber, Megan R. W. ;

Aldridge, Jerry R., Jr. ;

Webster, Robert G. ;

Magor, Katharine E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (13) :5913-5918

[5] In vivo genome editing using a high-efficiency TALEN system [J].

Bedell, Victoria M. ;

Wang, Ying ;

Campbell, Jarryd M. ;

Poshusta, Tanya L. ;

Starker, Colby G. ;

Krug, Randall G., II ;

Tan, Wenfang ;

Penheiter, Sumedha G. ;

Ma, Alvin C. ;

Leung, Anskar Y. H. ;

Fahrenkrug, Scott C. ;

Carlson, Daniel F. ;

Voytas, Daniel F. ;

Clark, Karl J. ;

Essner, Jeffrey J. ;

Ekker, Stephen C. .

NATURE, 2012, 491 (7422) :114-U133

[6] Contagious cancer: Lessons from the devil and the dog [J].

Belov, Katherine .

BIOESSAYS, 2012, 34 (04) :285-292

[7] The ferret as a model organism to study influenza A virus infection [J].

Belser, Jessica A. ;

Katz, Jacqueline M. ;

Tumpey, Terrence M. .

DISEASE MODELS & MECHANISMS, 2011, 4 (05) :575-579

[8] Lost in translation: Treatment trials in the SOD1 mouse and in human ALS [J].

Benatar, Michael .

NEUROBIOLOGY OF DISEASE, 2007, 26 (01) :1-13

[9] Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs [J].

Cade, Lindsay ;

Reyon, Deepak ;

Hwang, Woong Y. ;

Tsai, Shengdar Q. ;

Patel, Samir ;

Khayter, Cyd ;

Joung, J. Keith ;

Sander, Jeffry D. ;

Peterson, Randall T. ;

Yeh, Jing-Ruey Joanna .

NUCLEIC ACIDS RESEARCH, 2012, 40 (16) :8001-8010

[10] Targeted Genome Modification in Mice Using Zinc-Finger Nucleases [J].

Carbery, Iara D. ;

Ji, Diana ;

Harrington, Anne ;

Brown, Victoria ;

Weinstein, Edward J. ;

Liaw, Lucy ;

Cui, Xiaoxia .

GENETICS, 2010, 186 (02) :451-U37

← 1 2 3 4 5 6 7 8 →