Facile Conjugation of Biomolecules onto Surfaces via Mussel Adhesive Protein Inspired Coatings

被引：1383

作者：

Lee, Hoeshin ^{[1
]}

Rho, Junsung ^{[1
]}

Messersmith, Phillip B. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 04期

关键词：

ENZYME IMMOBILIZATION; INSECT CUTICLE;

D O I：

10.1002/adma.200801222

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new surface bioconjugation strategy is presented. A polydopamine surface coating provides chemical activation on material surfaces, is resistant to hydrolysis, and offers selectivity in coupling of biomolecules via nucleophilic groups through simple pH control. Control of orientation of immobilized biomolecules may be possible using terminally modified DNA or His-containing proteins.

引用

页码：431 / +

页数：5

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