DQB1*0602 confers genetic susceptibility to multiple sclerosis in Afro-Brazilians

被引：61

作者：

Caballero, A

Alvés-León, S

Papais-Alvarenga, R

Fernández, O

Navarro, G

Alonso, A ^{[1
]}

机构：

[1] Hosp Reg Carlos Haya, Serv Immunol, Malaga 29010, Spain

[2] Hosp Reg Carlos Haya, Serv Neurol, Malaga 29010, Spain

[3] Univ Fed Rio de Janeiro, Sch Med & Surg, Rio De Janeiro, Brazil

来源：

TISSUE ANTIGENS | 1999年 / 54卷 / 05期

关键词：

Afro-Brazilian; HLA; multiple sclerosis;

D O I：

10.1034/j.1399-0039.1999.540511.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We studied the distribution of the HLA-DRB1, -DQA1 and -DQB1 alleles in 44 Afro-Brazilian patients with multiple sclerosis and 88 controls. Although no significant differences were found between the patients and controls for the DRB1 and DQA1 alleles, the HLA-DQB1*0602 allele was positively associated with multiple sclerosis (45.0% vs. 17.0%, P-c=0.024, RR=3.31). The positive extended haplotypes for DQB1*0602 were more frequent in patients than controls, although the differences were not statistically significant in any of them. These results in Afro-Brazilians are in line with Other studies which have found DQB1*0602 to be associated with the disease in the absence of the DRB1*1501 allele. We therefore think that the association with the disease in this ethnic group is more allelic than haplotypic.

引用

页码：524 / 526

页数：3

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