A20: Central Gatekeeper in Inflammation and Immunity

被引：245

作者：

Coornaert, Beatrice

Carpentier, Isabelle

Beyaert, Rudi ^{[1
]}

机构：

[1] Univ Ghent, Dept Mol Biol, B-9052 Ghent, Belgium

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2009年 / 284卷 / 13期

关键词：

NF-KAPPA-B; ZINC-FINGER PROTEIN; SYSTEMIC-LUPUS-ERYTHEMATOSUS; DEPENDENT GENE-EXPRESSION; EDITING ENZYME A20; A20-BINDING INHIBITOR; RHEUMATOID-ARTHRITIS; RECEPTOR STIMULATION; SIGNALING PATHWAYS; NEGATIVE REGULATOR;

D O I：

10.1074/jbc.R800032200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inappropriate functioning of the immune system is linked to immune deficiency, autoimmune disease, and cancer. It is therefore not surprising that intracellular immune signaling pathways are tightly controlled. One of the best studied transcription factors in immune signaling is NF-kappa B, which is activated by multiple receptors and regulates the expression of a wide variety of proteins that control innate and adaptive immunity. A20 is an early NF-kappa B-responsive gene that encodes a ubiquitin-editing protein that is involved in the negative feedback regulation of NF-kappa B signaling. Here, we discuss the mechanism of action of A20 and its role in the regulation of inflammation and immunity.

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页码：8217 / 8221

页数：5

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