An adduct between peroxynitrite and 2'-deoxyguanosine: 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2'-deoxyguanosine

被引：96

作者：

Douki, T ^{[1
]}

Cadet, J ^{[1
]}

Ames, BN ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY, DIV BIOCHEM & MOLEC BIOL, BERKELEY, CA 94720 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 1996年 / 9卷 / 01期

关键词：

NITRIC-OXIDE; SUPEROXIDE-DISMUTASE; NITRATION; OXIDANTS;

D O I：

10.1021/tx950126n

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The reactivity of peroxynitrite (OONO-) with DNA is of interest because it is released during chronic inflammation, a major contributor to cancer. Peroxynitrite was found to undergo homolytic addition to the C4-C5 double bond of 2'-deoxyguanosine with formation of 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2'-deoxyguanosine (nox-dG). This adduct may be a useful marker in the study of the chemical processes associated with the mutagenicity of peroxynitrite.

引用

页码：3 / 7

页数：5

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