α1,3-fucoslytransferase IX (Fuc-TIX) is very highly conserved between human and mouse;: molecular cloning, characterization and tissue distribution of human Fuc-TIX

被引：97

作者：

Kaneko, M

Kudo, T

Iwasaki, H

Ikehara, Y

Nishihara, S

Nakagawa, S

Sasaki, K

Shiina, T

Inoko, H

Saitou, N

Narimatsu, H

机构：

[1] Soka Univ, Inst Life Sci, Div Cell Biol, Hachioji, Tokyo 1928577, Japan

[2] Grad Univ Adv Studies, Natl Inst Genet, Sch Life Sci, Dept Genet, Mishima, Shizuoka 4118540, Japan

[3] Kyowa Hakko Kogyo Co Ltd, Tokyo Res Labs, Machida, Tokyo 1948533, Japan

[4] Tokai Univ, Sch Med, Dept Mol Life Sci 2, Isehara, Kanagawa 2591193, Japan

来源：

FEBS LETTERS | 1999年 / 452卷 / 03期

关键词：

glycosyltransferase; fucosyltransferase; alpha 1,3-fucosyltransferase; Lewis x; CD15; SSEA-1;

D O I：

10.1016/S0014-5793(99)00640-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The amino acid sequence of Fuc-TIX is very highly conserved between mouse and human. The number of nonsynonymous nucleotide substitutions of the Fuc-TIX gene between human and mouse was strikingly low, and almost equivalent to that of the alpha-actin gene. This indicates that Fuc-TIX is under a strong selective pressure of preservation during evolution, The human Fuc-TIX (hFuc-TIX) showed a unique characteristics, i.e. hFuc-TIX was not activated by Mn2+ and Co2+, whereas hFuc-TIV and hFuc-TVI were activated by the cations, The hFuc-TIX transcripts were abundantly expressed in brain and stomach, and interestingly were detected in spleen and peripheral blood leukocytes, (C) 1999 Federation of European Biochemical Societies.

引用

页码：237 / 242

页数：6

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