Pityriarubins, biologically active bis(indolyl)spirans from cultures of the lipophilic yeast Malassezia furfur

被引：21

作者：

Irlinger, B

Krämer, HJ

Mayser, P

Steglich, W

机构：

[1] Univ Giessen, Zentrum Dermatol & Androl, D-35385 Giessen, Germany

[2] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 09期

关键词：

alkaloids; biosynthesis; skin diseases; yeasts;

D O I：

10.1002/anie.200352549

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Indole alkaloids, such as pityriarubin A (1), may be of importance for the pathogenesis of the common skin disease pityriasis versicolor. The metabolite 1 is produced in cultures of the lipophilic yeast Malassezia furfur with tryptophan present as the sole source of nitrogen. The structures of the pityriarubins were derived from spectroscopic investigations, and insight into their biosynthesis was gained by feeding experiments with [1′- 13C]tryptophan.

引用

页码：1098 / 1100

页数：3

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