Biofunctional micellar nanoparticles from peptide-b-polymer chimeras

被引：13

作者：

Drappier, Charlotte ^{[1
,2
]}

Wirotius, Anne-Laure ^{[1
]}

Bathany, Katell ^{[3
]}

Ibarboure, Emmanuel ^{[1
]}

Condassamy, Olivia ^{[1
]}

Garanger, Elisabeth ^{[1
,2
]}

Lecommandoux, Sebastien ^{[1
]}

机构：

[1] Univ Bordeaux, CNRS, UMR 5629, LCPO, F-33607 Pessac, France

[2] IECB, F-33607 Pessac, France

[3] Univ Bordeaux, CNRS, UMR 5248, CBMN,PGF, F-33076 Bordeaux, France

来源：

POLYMER CHEMISTRY | 2013年 / 4卷 / 06期

关键词：

INTRACELLULAR DRUG-DELIVERY; CELL-PENETRATING PEPTIDES; SYNTHETIC-POLYMER; BLOCK-COPOLYMERS; TAT PEPTIDE; PROTEIN; MEMBRANE; SIRNA; HIV-1; SPECTROSCOPY;

D O I：

10.1039/c2py21044d

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We describe the precision synthesis and characterization of amphiphilic peptide-b-polymer chimeras encoding, at the molecular level, self-assembly properties and biological functions, presently cell membrane penetrating motifs (Tat peptide). Self-assembled micellar nanoparticles obtained from a series of Tat-b-poly(trimethylene carbonate) (Tat-b-PTMC) chimeras with tunable hydrophilic fractions were finely characterized in order to establish chimera-nanoparticle structure relationships. Well-defined nanoparticles with diameters ranging from 22 to 40 nm could be obtained by direct self-assembly in buffer.

引用

页码：2011 / 2018

页数：8

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