Enantioselective synthesis of the C1-C9 segment of bryostatin by kinetic resolution of racemic alpha-keto esters

被引：24

作者：

Kalesse, M

Eh, M

机构：

[1] Institut für Organische Chemie, Universität Hannover, 30167 Hannover

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 11期

关键词：

D O I：

10.1016/0040-4039(96)00172-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective synthesis of the C1-C9 segment of bryostatins is described. Racemic beta-keto ester 2 was subjected to kinetic resolution. Reduction with baker's yeast establishes two of the three chiral centers. Chemical transformation of the terminal acetylene moiety generates aldehyde 5 which is transformed diastereoselectively to the corresponding alcohol 6 via Sakurai reaction.

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页码：1767 / 1770

页数：4

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