Parthenolide: from plant shoots to cancer roots

被引：315

作者：

Ghantous, Akram ^{[1
]}

Sinjab, Ansam ^{[2
]}

Herceg, Zdenko ^{[1
]}

Darwiche, Nadine ^{[3
]}

机构：

[1] Int Agcy Res Canc, F-69372 Lyon, France

[2] German Canc Res Ctr, Heidelberg, Germany

[3] Amer Univ Beirut, Biochem & Mol Genet Dept, Beirut, Lebanon

来源：

DRUG DISCOVERY TODAY | 2013年 / 18卷 / 17-18期

关键词：

NF-KAPPA-B; SESQUITERPENE LACTONE PARTHENOLIDE; MYELOGENOUS LEUKEMIA STEM; SUPPRESSES TUMOR-GROWTH; CELLS IN-VITRO; COMBINATION THERAPY; IMPROVES SURVIVAL; INDUCED APOPTOSIS; XENOGRAFT MODEL; MELANOMA-CELLS;

D O I：

10.1016/j.drudis.2013.05.005

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Parthenolide (PTL), a sesquiterpene lactone (SL) originally purified from the shoots of feverfew (Tanacetum parthenium), has shown potent anticancer and anti-inflammatory activities. It is currently being tested in cancer clinical trials. Structure-activity relationship (SAR) studies of parthenolide revealed key chemical properties required for biological activities and epigenetic mechanisms, and led to the derivatization of an orally bioavailable analog, dimethylamino-parthenolide (DMAPT). Parthenolide is the first small molecule found to be selective against cancer stem cells (CSC), which it achieves by targeting specific signaling pathways and killing cancer from its roots. In this review, we highlight the exciting journey of parthenolide, from plant shoots to cancer roots.

引用

收藏

页码：894 / 905

页数：12

相关论文

共 83 条

[1]

PARTHENOLIDE CONTENT OF FEVERFEW (TANACETUM-PARTHENIUM)ASSESSED BY HPLC AND H-1-NMR SPECTROSCOPY [J].

AWANG, DVC ;

DAWSON, BA ;

KINDACK, DG ;

CROMPTON, CW ;

HEPTINSTALL, S .

JOURNAL OF NATURAL PRODUCTS, 1991, 54 (06) :1516-1521

[2]

Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions [J].

Birnie, Richard ;

Bryce, Steven D. ;

Roome, Claire ;

Dussupt, Vincent ;

Droop, Alastair ;

Lang, Shona H. ;

Berry, Paul A. ;

Hyde, Catherine F. ;

Lewis, John L. ;

Stower, Michael J. ;

Maitland, Norman J. ;

Collins, Anne T. .

GENOME BIOLOGY, 2008, 9 (05)

[3]

NATURALLY-OCCURRING TERPENE DERIVATIVES .454. SESQUITERPENE LACTONES AND OTHER CONSTITUENTS FROM TANACETUM-PARTHENIUM [J].

BOHLMANN, F ;

ZDERO, C .

PHYTOCHEMISTRY, 1982, 21 (10) :2543-2549

[4]

Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappa B [J].

Bork, PM ;

Schmitz, ML ;

Kuhnt, M ;

Escher, C ;

Heinrich, M .

FEBS LETTERS, 1997, 402 (01) :85-90

[5]

Cheng Deping, 2005, Proceedings of the American Association for Cancer Research Annual Meeting, V46, P988

[6]

Crooks P.A., 2012, Patent number, Patent No. [US 7312242, 7312242]

[7]

Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres [J].

Czyz, Malgorzata ;

Koprowska, Kamila ;

Sztiller-Sikorska, Malgorzata .

CANCER BIOLOGY & THERAPY, 2013, 14 (02) :135-145

[8]

Inhibition of NF-κB and metalloproteinase-9 expression and secretion by parthenolide derivatives [J].

Dell'Agli, Mario ;

Galli, Germana V. ;

Bosisio, Enrica ;

D'Ambrosio, Michele .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (07) :1858-1860

[9]

Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-κB pathways [J].

Dey, Anwesha ;

Tergaonkar, Vinay ;

Lane, David P. .

NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (12) :1031-1040

[10]

Parthenolide eliminates leukemia-initiating cell populations and improves survival in xenografts of childhood acute lymphoblastic leukemia [J].

Diamanti, Paraskevi ;

Cox, Charlotte V. ;

Moppett, John P. ;

Blair, Allison .

BLOOD, 2013, 121 (08) :1384-1393

← 1 2 3 4 5 6 7 8 9 →