Neuropathologic findings in essential tremor

被引：111

作者：

Louis, ED

Vonsattel, JPG

Honig, LS

Ross, GW

Lyons, KE

Pahwa, R

机构：

[1] Columbia Univ Coll Phys & Surg, GH Sergievsky Ctr, New York, NY 10032 USA

[2] Columbia Univ Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA

[3] Columbia Univ Coll Phys & Surg, Taub Inst Res & Alzheimers Dis & Aging Brain, New York, NY 10032 USA

[4] Columbia Univ Coll Phys & Surg, Dept Pathol, New York, NY 10032 USA

[5] Vet Affairs Pacific Isl Hlth care Syst, Honolulu, HI USA

[6] Univ Hawaii, John A Burns Sch Med, Dept Med, Honolulu, HI 96822 USA

[7] Univ Hawaii, John A Burns Sch Med, Dept Geriatr, Honolulu, HI 96822 USA

[8] Kuakini Med Ctr, Honolulu Asia Aging Study, Pacific Hlth Res Inst, Honolulu, HI USA

[9] Univ Kansas, Med Ctr, Dept Neurol, Kansas City, KS USA

来源：

NEUROLOGY | 2006年 / 66卷 / 11期

关键词：

D O I：

10.1212/01.wnl.0000218162.80315.b9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Pathologic findings, including cerebellar changes and brainstem Lewy bodies, distinguished 10 essential tremor (ET) cases from 12 controls. Numbers of torpedoes (p = 0.009) and Bergmann glia (p = 0.046) were increased in cases. Six cases (60%) had Lewy bodies vs 2 controls (16.7%) (odds ratio 7.5, 95% CI 1.04 to 54.1; p = 0.035). Four of these six had an atypical distribution of brainstem Lewy bodies. ET may be pathologically heterogeneous.

引用

页码：1756 / 1759

页数：4

共 10 条

[1] Staging of brain pathology related to sporadic Parkinson's disease
Braak, H
Del Tredici, K
Rüb, U
de Vos, RAI
Steur, ENHJ
Braak, E
[J]. NEUROBIOLOGY OF AGING, 2003, 24 (02) : 197 - 211
[2] Lewy body-related α-synucleinopathy in the aged human brain
Jellinger, KA
[J]. JOURNAL OF NEURAL TRANSMISSION, 2004, 111 (10-11) : 1219 - 1235
[3] Essential tremor associated with focal nonnigral Lewy bodies - A clinicopathologic study
Louis, ED
Honig, LS
Vonsattel, JPG
Maraganore, DM
Borden, S
Moskowitz, CB
[J]. ARCHIVES OF NEUROLOGY, 2005, 62 (06) : 1004 - 1007
[4] Metabolic abnormality in the cerebellum in patients with essential tremor: a proton magnetic resonance spectroscopic imaging study
Louis, ED
Shungu, DC
Chan, S
Mao, XL
Jurewicz, EC
Watner, D
[J]. NEUROSCIENCE LETTERS, 2002, 333 (01) : 17 - 20
[5] MIZUSHIMA S, 1976, J CLIN ELECT MICROSC, V9, P5
[6] α-Synuclein pathology does not predict extrapyramidal symptoms or dementia
Parkkinen, L
Kauppinen, T
Pirttilä, T
Autere, JM
Alafuzoff, I
[J]. ANNALS OF NEUROLOGY, 2005, 57 (01) : 82 - 91
[7] Essential tremor course and disability - A clinicopathologic study of 20 cases
Rajput, A
Robinson, CA
Rajput, AH
[J]. NEUROLOGY, 2004, 62 (06) : 932 - 936
[8] Ross GW, 2004, NEUROLOGY, V62, pA537
[9] Lewy body-related α-synucleinopathy in aging
Saito, Y
Ruberu, NN
Sawabe, M
Arai, T
Kazama, H
Hosoi, T
Yamanouchi, H
Murayama, S
[J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2004, 63 (07) : 742 - 749
[10] Wang Y, 1999, J PHARMACOL EXP THER, V288, P211

← 1 →