Disseminated and circulating tumor cells in gastrointestinal oncology

被引:30
作者
Bidard, F. C. [1 ]
Ferrand, F. R. [2 ]
Huguet, F. [3 ]
Hammel, P. [4 ]
Louvet, C. [5 ]
Malka, D. [6 ]
Boige, V. [6 ]
Ducreux, M. [6 ]
Andre, T. [7 ]
de Gramont, A. [7 ]
Mariani, P. [8 ]
Pierga, J. Y. [1 ,9 ]
机构
[1] Inst Curie, Dpt Med Oncol, F-75005 Paris, France
[2] Hop Instruct Armees Val de Grace, Dpt Med Oncol, Paris, France
[3] Hop Tenon, Dpt Radiat Oncol, F-75970 Paris, France
[4] Hop Beaujon, Dpt Gastroenterol, Clichy, France
[5] Inst Mutualiste Montsouris, Dpt Med Oncol, Paris, France
[6] Inst Gustave Roussy, Dpt Med Oncol, Villejuif, France
[7] Hop St Antoine, Dpt Med Oncol, F-75571 Paris, France
[8] Inst Curie, Dpt Surg, F-75005 Paris, France
[9] Univ Paris 05, Paris, France
关键词
Gastrointestinal cancer; Circulating tumor cells; Disseminated tumor cells; Micrometastasis; Biomarker; POLYMERASE CHAIN-REACTION; FETOPROTEIN MESSENGER-RNA; BONE-MARROW MICROMETASTASES; DISSEMINATED CANCER-CELLS; HEPATOCELLULAR-CARCINOMA CELLS; METASTATIC BREAST-CANCER; MINIMAL RESIDUAL DISEASE; E-CADHERIN EXPRESSION; PERIPHERAL-BLOOD; GASTRIC-CANCER;
D O I
10.1016/j.critrevonc.2011.05.008
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Circulating (CTCs) and disseminated tumor cells (DTCs) are two different steps in the metastatic process. Several recent techniques have allowed detection of these cells in patients, and have generated many results using different isolation techniques in small cohorts. Herein, we review the detection results and their clinical consequence in esophageal, gastric, pancreatic, colorectal, and liver carcinomas, and discuss their possible applications as new biomarkers. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:103 / 115
页数:13
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