Naloxone-insensitive inhibition of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by the novel opioid, nociceptin

被引：74

作者：

Patel, HJ ^{[1
]}

Giembycz, MA ^{[1
]}

Spicuzza, L ^{[1
]}

Barnes, PJ ^{[1
]}

Belvisi, MG ^{[1
]}

机构：

[1] NATL HEART & LUNG INST,IMPERIAL COLL SCH MED,LONDON SW3 6LY,ENGLAND

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1997年 / 120卷 / 05期

关键词：

cholinergic neurotransmission; opioids; nociceptin; airways; parasympathetic nerves;

D O I：

10.1038/sj.bjp.0701013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The novel peptide, nociceptin and the mu-opioid agonist [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin (DAMGO) produced a concentration-dependent inhibition of electrical held stimulation (EFS)-evoked release of acetylcholine (ACh) from cholinergic nerves innervating guinea-pig trachea. The non-selective opioid receptor antagonist, naloxone, did not antagonize the inhibitory action of nociceptin under conditions where the inhibition of ACh release evoked by DAMGO was completely reversed. It is suggested that DAMGO and nociceptin can inhibit cholinergic, parasympathetic neurotransmission to the airways via the activation of classical (naloxone-sensitive) and novel (naloxone-insensitive) opioid receptors, respectively.

引用

页码：735 / 736

页数：2

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