Pathogenic and protective role of macrophages in kidney disease

被引：63

作者：

Cao, Qi ^{[1
]}

Wang, Yiping ^{[1
]}

Harris, David C. H. ^{[1
]}

机构：

[1] Univ Sydney, Westmead Millennium Inst, Ctr Transplantat & Renal Res, Sydney, NSW 2006, Australia

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2013年 / 305卷 / 01期

基金：

英国医学研究理事会;

关键词：

macrophages; kidney disease; cell therapy; ANTI-GBM GLOMERULONEPHRITIS; MURINE PERITONEAL-MACROPHAGES; ISCHEMIA-REPERFUSION INJURY; TUBULAR EPITHELIAL-CELLS; MEDIATED RENAL INJURY; NECROSIS-FACTOR-ALPHA; REGULATORY T-CELLS; LUPUS NEPHRITIS; INTERSTITIAL MACROPHAGES; OBSTRUCTIVE NEPHROPATHY;

D O I：

10.1152/ajprenal.00122.2013

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Macrophages (M Phi) are located throughout kidney tissue, where they play important roles in homeostasis, surveillance, tolerance, and cytoprotection. M Phi are highly heterogeneous cells and exhibit distinct phenotypic and functional characteristics depending on their microenvironment and the disease type and stage. Recent studies have identified a dual role for M Phi in several murine models of kidney disease. In this review, we discuss the pathogenic and protective roles of the various M Phi subsets in experimental and human kidney diseases and summarize current progress toward the therapeutic use of M Phi in kidney diseases.

引用

页码：F3 / F11

页数：9

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