Polysubstance abuse-vulnerability genes: Genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms

被引：198

作者：

Uhl, GR

Liu, QR

Walther, D

Hess, J

Naiman, D

机构：

[1] NIDA, Mol Neurobiol Branch, NIH, Baltimore, MD USA

[2] Johns Hopkins Univ, Dept Math Sci, Baltimore, MD 21218 USA

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 2001年 / 69卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1086/324467

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Strong genetic contributions to drug abuse vulnerability are well documented, but few chromosomal locations for human drug-abuse vulnerability alleles have been confirmed. We now identify chromosomal markers whose alleles distinguish drug abusers from control individuals in each of two samples, on the basis of pooled-sample microarray and association analyses. Reproducibly positive chromosomal regions defined by these markers in conjunction with previous results were especially unlikely to have been identified by chance. Positive markers identify the alcohol dehydrogenase (ADH) locus, flank the brain-derived neurotropic factor (BDNF) locus, and mark seven other regions previously linked to vulnerability to nicotine or alcohol abuse. These data support polygenic contributions of common allelic variants to polysubstance abuse vulnerability.

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收藏

页码：1290 / 1300

页数：11

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