Practical route to a new class of LTD(4) receptor antagonists

被引：247

作者：

Larsen, RD ^{[1
]}

Corley, EG ^{[1
]}

King, AO ^{[1
]}

Carroll, JD ^{[1
]}

Davis, P ^{[1
]}

Verhoeven, TR ^{[1
]}

Reider, PJ ^{[1
]}

Labelle, M ^{[1
]}

Gauthier, JY ^{[1
]}

Xiang, YB ^{[1
]}

Zamboni, RJ ^{[1
]}

机构：

[1] MERCK & CO INC,MERCK FROSST CTR THERAPEUT RES,POINTE CLAIRE,PQ H9R 4P8,CANADA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 10期

关键词：

D O I：

10.1021/jo952103j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general approach to the synthesis of a new class of LTD(4) antagonists is presented. The key diarylpropane framework was prepared by Claisen-Schmidt condensation and selective reduction of the enone. Depending on the bridge to the 7-chloroquinaldine moiety, alkylation or Heck coupling methodology was developed. The chiral sulfides were introduced by asymmetric reduction of the diarylpropanone intermediates and subsequent inversion of the chiral center.

引用

页码：3398 / 3405

页数：8

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