NO signaling in ARE-mediated gene expression

被引：12

作者：

Park, EY ^{[1
]}

Kim, SG ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

NITRIC OXIDE, PT E | 2005年 / 396卷

基金：

新加坡国家研究基金会;

关键词：

D O I：

10.1016/S0076-6879(05)96028-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide (NO) and peroxynitrite, which serve as cell signal molecules, activate the antioxidant response element (ARE) for the induction of phase 11 antioxidant enzymes as an adaptive response. The reactive nitrogen species plays an essential role in Nrf2 activation and Nrf.2 binding to the ARE present in the target genes. In this chapter, we describe the system by which the NO signaling pathway regulates ARE-mediated gene expression, which includes immunochemical assessment and gel shift analysis of Nrf2 activation.

引用

收藏

页码：341 / 349

页数：9

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