Three novel rearranged cholestane glycosides from Ornithogalum saundersiae bulbs and their cytostatic activities on leukemia HL-60 and MOLT-4 cells

被引：27

作者：

Mimaki, Y ^{[1
]}

Kuroda, M ^{[1
]}

Sashida, Y ^{[1
]}

Hirano, T ^{[1
]}

Oka, K ^{[1
]}

Dobashi, A ^{[1
]}

Koshino, H ^{[1
]}

Uzawa, J ^{[1
]}

机构：

[1] INST PHYS & CHEM RES,WAKO,SAITAMA 35101,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 08期

关键词：

D O I：

10.1016/0040-4039(95)02407-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three novel rearranged cholestane glycosides (1-3) were isolated form Ornithogalum saundersiae bulbs. Their structures were determined by spectroscopic analysis. The conformation of the E-ring part of the cholestanes was studied through molecular mechanics and molecular dynamics calculation methods. Compound 3 embracing an acyl group at the saccharide part strongly suppressed the growth of leukemia HL-60 cells, which was mediated partially through induction of apoptosis.

引用

页码：1245 / 1248

页数：4

共 7 条

[1] NMR-SPECTROSCOPY IN THE STRUCTURAL ELUCIDATION OF OLIGOSACCHARIDES AND GLYCOSIDES [J].