Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma

被引：688

作者：

Hernandez-Gea, Virginia ^{[1
,2
]}

Toffanin, Sara ^{[1
,3
,4
]}

Friedman, Scott L. ^{[1
,3
]}

Llovet, Josep M. ^{[1
,2
,3
,5
]}

机构：

[1] Mt Sinai Sch Med, Div Liver Dis, New York, NY 10029 USA

[2] Univ Barcelona, Barcelona Clin Liver Canc Grp, HCC Translat Res Lab,Hosp Clin, Inst Invest Biomed August Pi & Sunyer,Liver Unit, Catalonia, Spain

[3] Mt Sinai Sch Med, Mt Sinai Liver Canc Program, Div Liver Dis, Tisch Canc Inst, New York, NY 10029 USA

[4] IRCSS Fdn, NCI, Gastrointestinal Surg & Liver Transplantat Unit, Milan, Italy

[5] Inst Catalana Recerca & Estudis Avancats, Catalonia, Spain

来源：

GASTROENTEROLOGY | 2013年 / 144卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Liver Cancer; Extracellular Matrix; Angiogenesis; Chemoprevention; NF-KAPPA-B; TUMOR-ASSOCIATED MACROPHAGES; GROWTH-FACTOR GENE; CANCER STEM-CELLS; EXTRACELLULAR-MATRIX; STROMAL FIBROBLASTS; POOR-PROGNOSIS; FUNCTIONAL POLYMORPHISM; SIGNALING PATHWAY; OXIDATIVE STRESS;

D O I：

10.1053/j.gastro.2013.01.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatocellular carcinoma (HCC) is the most common primary liver tumor and the third greatest cause of cancer-related death worldwide, and its incidence is increasing. Despite the significant improvement in management of HCC over the past 30 years, there are no effective chemoprevention strategies, and only one systemic therapy has been approved for patients with advanced tumors. This drug, sorafenib, acts on tumor cells and the stroma. HCC develops from chronically damaged tissue that contains large amounts of inflammation and fibrosis, which also promote tumor progression and resistance to therapy. Increasing our understanding of how stromal components interact with cancer cells and the signaling pathways involved could help identify new therapeutic and chemopreventive targets.

引用

页码：512 / 527

页数：16

共 148 条

[1] Transforming growth factor betas and their signaling receptors in human hepatocellular carcinoma [J].

Abou-Shady, M ;

Baer, HU ;

Friess, H ;

Berberat, P ;

Zimmermann, A ;

Graber, H ;

Gold, LI ;

Korc, M ;

Büchler, MW .

AMERICAN JOURNAL OF SURGERY, 1999, 177 (03) :209-215

[2] A Functional Polymorphism in the Epidermal Growth Factor Gene Is Associated With Risk for Hepatocellular Carcinoma [J].

Abu Dayyeh, Barham K. ;

Yang, May ;

Fuchs, Bryan C. ;

Karl, Daniel L. ;

Yamada, Suguru ;

Sninsky, John J. ;

O'Brien, Thomas R. ;

Dienstag, Jules L. ;

Tanabe, Kenneth K. ;

Chung, Raymond T. .

GASTROENTEROLOGY, 2011, 141 (01) :141-149

[3] Therapeutic targeting of a stem cell niche [J].

Adams, Gregor B. ;

Martin, Roderick P. ;

Alley, Ian R. ;

Chabner, Karissa T. ;

Cohen, Kenneth S. ;

Calvi, Laura M. ;

Kronenberg, Henry M. ;

Scadden, David T. .

NATURE BIOTECHNOLOGY, 2007, 25 (02) :238-243

[4] Costimulation by extracellular matrix proteins determines the response to TCR ligation [J].

Adler, B ;

Ashkar, S ;

Cantor, H ;

Weber, GF .

CELLULAR IMMUNOLOGY, 2001, 210 (01) :30-40

[5] Molecular characterization of the tumor microenvironment in breast cancer [J].

Allinen, M ;

Beroukhim, R ;

Cai, L ;

Brennan, C ;

Lahti-Domenici, J ;

Huang, HY ;

Porter, D ;

Hu, M ;

Chin, L ;

Richardson, A ;

Schnitt, S ;

Sellers, WR ;

Polyak, K .

CANCER CELL, 2004, 6 (01) :17-32

[6] Reduced Expression of Fibroblast Growth Factor Receptor 2IIIb in Hepatocellular Carcinoma Induces a More Aggressive Growth [J].

Amann, Thomas ;

Bataille, Frauke ;

Spruss, Thilo ;

Dettmer, Katja ;

Wild, Peter ;

Liedtke, Christian ;

Muehlbauer, Marcus ;

Kiefer, Paul ;

Oefner, Peter J. ;

Trautwein, Christian ;

Bosserhoff, Anja-Katrin ;

Hellerbrand, Claus .

AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (03) :1433-1442

[7] Oncogenic β-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice [J].

Anson, Marie ;

Crain-Denoyelle, Anne-Marie ;

Baud, Veronique ;

Chereau, Fanny ;

Gougelet, Angelique ;

Terris, Benoit ;

Yamagoe, Satoshi ;

Colnot, Sabine ;

Viguier, Mireille ;

Perret, Christine ;

Couty, Jean-Pierre .

JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (02) :586-599

[8] Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis [J].

Baek, Hye Jung ;

Lim, Sung Chul ;

Kitisin, Krit ;

Jogunoori, Wilma ;

Tang, Yi ;

Marshall, M. Blair ;

Mishra, Bibhuti ;

Kim, Tae Hyun ;

Cho, Kwan Ho ;

Kim, Sang Soo ;

Mishra, Lopa .

HEPATOLOGY, 2008, 48 (04) :1128-1137

[9] Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment [J].

Barry-Hamilton, Vivian ;

Spangler, Rhyannon ;

Marshall, Derek ;

McCauley, Scott ;

Rodriguez, Hector M. ;

Oyasu, Miho ;

Mikels, Amanda ;

Vaysberg, Maria ;

Ghermazien, Haben ;

Wai, Carol ;

Garcia, Carlos A. ;

Velayo, Arleene C. ;

Jorgensen, Brett ;

Biermann, Donna ;

Tsai, Daniel ;

Green, Jennifer ;

Zaffryar-Eilot, Shelly ;

Holzer, Alison ;

Ogg, Scott ;

Thai, Dung ;

Neufeld, Gera ;

Van Vlasselaer, Peter ;

Smith, Victoria .

NATURE MEDICINE, 2010, 16 (09) :1009-U107

[10] Increased levels of interleukin-10 in serum from patients with hepatocellular carcinoma correlate with profound numerical deficiencies and immature phenotype of circulating dendritic cell subsets [J].

Beckebaum, S ;

Zhang, X ;

Chen, X ;

Yu, ZY ;

Frilling, A ;

Dworacki, G ;

Grosse-Wilde, H ;

Broelsch, CE ;

Gerken, G ;

Cicinnati, VR .

CLINICAL CANCER RESEARCH, 2004, 10 (21) :7260-7269

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