High-resolution full-field optical coherence tomography with a Linnik microscope

被引：474

作者：

Dubois, A ^{[1
]}

Vabre, L ^{[1
]}

Boccara, AC ^{[1
]}

Beaurepaire, E ^{[1
]}

机构：

[1] Ecole Super Phys & Chim Ind Ville Paris, F-75231 Paris 5, France

来源：

APPLIED OPTICS | 2002年 / 41卷 / 04期

关键词：

D O I：

10.1364/AO.41.000805

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We describe an original microscope for high-resolution optical coherence tomography applications. Our system is based on a Linnik interference microscope with high-numerical-aperture objectives. Lock-in detection of the interference signal is achieved in parallel on a CCD by use of a photoelastic birefiringence modulator and full-field stroboscopic illumination with an infrared LED. Transverse cross-section (en-face, or XY) images can be obtained in real time with better than 1-mum axial (Z) resolution and 0.5-mum transverse (XY) resolution. A sensitivity of similar to80 dB is reached at a 1-image/s acquisition rate, which allows tomography in scattering media such as biological tissues. (C) 2002 Optical Society of America.

引用

页码：805 / 812

页数：8

共 27 条

[1]

[Anonymous], 1990, CONFOCAL MICROSCOPY

[2] Combined scanning optical coherence and two-photon-excited fluorescence microscopy [J].

Beaurepaire, E ;

Moreaux, L ;

Amblard, F ;

Mertz, J .

OPTICS LETTERS, 1999, 24 (14) :969-971

[3]

Bizheva K. K., 2001, WAVES IMAGING COMPLE, P277

[4]

Boccara A. C., 1990, Frenchpatent, Patent No. [FR90.092255, 90092255]

[5] In vivo cellular optical coherence tomography imaging [J].

Boppart, SA ;

Bouma, BE ;

Pitris, C ;

Southern, JF ;

Brezinski, ME ;

Fujimoto, JG .

NATURE MEDICINE, 1998, 4 (07) :861-865

[6]

Born M., 1993, PRINCIPLES OPTICS

[7] HIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHIC IMAGING USING A MODE-LOCKED TI-AL2O3 LASER SOURCE [J].

BOUMA, B ;

TEARNEY, GJ ;

BOPPART, SA ;

HEE, MR ;

BREZINSKI, ME ;

FUJIMOTO, JG .

OPTICS LETTERS, 1995, 20 (13) :1486-1488

[8] NEW DESIGN FOR A PHOTO-ELASTIC MODULATOR [J].

CANIT, JC ;

BADOZ, J .

APPLIED OPTICS, 1983, 22 (04) :592-594

[9]

Creath K., 1988, Progress in optics. Vol.XXVI, P349, DOI 10.1016/S0079-6638(08)70178-1

[10]

Davidson M., 1987, Proceedings of the SPIE - The International Society for Optical Engineering, V775, P233, DOI 10.1117/12.940433

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