Towards a general triple helix mediated DNA recognition scheme

被引：71

作者：

Doronina, SO

Behr, JP

机构：

[1] Laboratiore de Chim. Genet. A., ULP, Faculté de Pharmacie, F-67401 Illkirch Cedex

来源：

CHEMICAL SOCIETY REVIEWS | 1997年 / 26卷 / 01期

关键词：

D O I：

10.1039/cs9972600063

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review describes new perspectives offered by the synthesis of non-natural nucleosides to overcome current limitations and extend the tripler-mediated DNA recognition scheme to any sequence, Alternate strand purine binding, direct pyrimidine recognition, and binding to the whole base-pair are described. The review highlights structural requirements to the design of modified nucleosides, as well as perturbing events such as tautomeric ambiguity and intercalation for the extended heterocyclic bases.

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页码：63 / 71

页数：9

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