Rheological study on hyaluronic acid and its derivative solutions

被引：61

作者：

Ambrosio, L ^{[1
]}

Borzacchiello, A ^{[1
]}

Netti, PA ^{[1
]}

Nicolais, L ^{[1
]}

机构：

[1] Univ Naples Federico II, Inst Composite Mat Technol, CNR, Interdisciplinary Res Ctr Biomat, Naples, Italy

来源：

JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY | 1999年 / A36卷 / 7-8期

关键词：

hyaluronic acid; polysaccharides; rheology; viscosity; viscoelasticity; molecular weight; concentration;

D O I：

10.1080/10601329908951195

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Rheological measurements were performed an Hyaluronic acid (HA) and its derivative solutions to evaluate steady flow viscosity and dynamics response with the aim to correlate the materials properties to the concentration, molecular weight and chemical structure. At low molecular weight and concentration, the HA solutions behaved as viscous liquid, whereas a soft-gel response was evident at higher molecular weight and concentration due to chains entanglement. Increasing the molecular weight was more effective than increasing concentration in promoting entanglement of molecular chains of HA. Comparing the behavior of HA solutions with that of Hyaluronic acid derivatives, it is showed that it is possible to modulate the rheological properties of HA based solutions by chemical modification preserving the biocompatibility of the materials. The results of the rheological analysis provide a valuable tool to properly design optimal substitutes for specific biomedical application.

引用

页码：991 / 1000

页数：10

共 11 条

[1]

BALAZS EA, 1993, J RHEUMATOL, V20, P3

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