An elasticity microscope .1. Methods

被引：73

作者：

Cohn, NA ^{[1
]}

Emelianov, SY ^{[1
]}

Lubinski, MA ^{[1
]}

ODonnell, M ^{[1
]}

机构：

[1] UNIV MICHIGAN, DEPT ELECT ENGN & COMP SCI, ANN ARBOR, MI 48109 USA

来源：

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL | 1997年 / 44卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1109/58.656634

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

An elasticity microscope images tissue stiffness at fine resolution. Possible applications include dermatology, ophthalmology, pathology and tissue engineering. In addition, if the resolution approaches cellular dimensions, then this system may be very useful in understanding tissue micromorphology. Elasticity images can be reconstructed from displacement and strain fields measured throughout the specimen during controlled external loading. High frequency ultrasound is used to obtain these images by tracking coherent speckle motion during deformation. In this paper, methods are presented to track speckle in two dimensions with near unity correlation coefficients using a high frequency, single element focused transducer. These techniques include improved means for speckle tracking. Procedures to control boundary conditions for consistent specimen deformation and scanning techniques required to obtain a plane-strain state in the imaging plane are also discussed. To test these methods, a 50 Milt elasticity microscope was constructed.

引用

页码：1304 / 1319

页数：16

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