The assessment of topical nasal drug distribution

被引：86

作者：

Aggarwal, R ^{[1
]}

Cardozo, A ^{[1
]}

Homer, JJ ^{[1
]}

机构：

[1] Manchester Royal Infirm, Dept Otolaryngol Head & Neck Surg, Manchester M13 9DL, Lancs, England

来源：

CLINICAL OTOLARYNGOLOGY | 2004年 / 29卷 / 03期

关键词：

drug delivery; intranasal; rhinitis; sinusitis; nasal polyps;

D O I：

10.1111/j.1365-2273.2004.00797.x

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The mainstay of treatment of chronic rhinosinusitis is through the administration of topical nasal drugs. The delivery and intranasal distribution of these is therefore of potential clinical significance. Until there is progress in the nasal drug distribution assessment methodology, it will be difficult to improve topical nasal drug delivery, which is known to be suboptimal in many ways. This study reviews intranasal drug delivery assessment methods, the present knowledge and explores future directions for research.

引用

页码：201 / 205

页数：5

共 27 条

[1] DISTRIBUTION AND REMOVAL OF HUMAN-SERUM ALBUMIN TC-99M 99M INSTILLED INTRANASALLY [J].

AOKI, FY ;

CRAWLEY, JCW .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1976, 3 (05) :869-878

[2] A study of intranasal distribution of azelastine hydrochloride aqueous nasal spray with different spray techniques [J].

Bateman, ND ;

Whymark, AD ;

Clifton, NJ ;

Woolford, TJ .

CLINICAL OTOLARYNGOLOGY, 2002, 27 (05) :327-330

[3] Deposition and disposition of [11C]zanamivir following administration as an intranasal spray -: Evaluation with positron emission tomography [J].

Bergstrom, M ;

Cass, LMR ;

Valind, S ;

Westerberg, G ;

Lundberg, EL ;

Gray, S ;

Bye, A ;

Langstrom, B .

CLINICAL PHARMACOKINETICS, 1999, 36 (Suppl 1) :33-39

[4]

Berridge MS, 1998, J NUCL MED, V39, P1972

[5] Comparison of the clearance of radiolabelled nose drops and nasal spray as mucosally delivered vaccine [J].

Bryant, ML ;

Brown, P ;

Gurevich, N ;

McDougall, IR .

NUCLEAR MEDICINE COMMUNICATIONS, 1999, 20 (02) :171-174

[6] DOUBLE-BLIND, PLACEBO CONTROLLED TRIAL OF BETAMETHASONE NASAL DROPS FOR NASAL POLYPOSIS [J].

CHALTON, R ;

MACKAY, I ;

WILSON, R ;

COLE, P .

BRITISH MEDICAL JOURNAL, 1985, 291 (6498) :788-788

[7] The effect of inferior turbinate hypertrophy on nasal spray distribution to the middle meatus [J].

Dowley, AC ;

Homer, JJ .

CLINICAL OTOLARYNGOLOGY, 2001, 26 (06) :488-490

[8]

DRAKELEE AB, 1997, SCOTTBROWNS OTOLARYN

[9] The effect of six weeks topical nasal betamethasone drops on the hypothalamo-pituitary-adrenal axis and bone turnover in patients with nasal polyposis [J].

Gazis, AG ;

Homer, JJ ;

Henson, DB ;

Page, SR ;

Jones, NS .

CLINICAL OTOLARYNGOLOGY, 1999, 24 (06) :495-498

[10] A COMPARISON OF THE REGIONAL DEPOSITION IN A MODEL NOSE OF A DRUG DISCHARGED FROM METERED AEROSOL AND METERED-PUMP NASAL DELIVERY SYSTEMS [J].

HALLWORTH, GW ;

PADFIELD, JM .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1986, 77 (02) :348-353

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