Electrical detection of femtomolar DNA via gold-nanoparticle enhancement in carbon-nanotube-network field-effect transistors

被引：91

作者：

Dong, Xiaochen ^{[1
,2
]}

Lau, Ching Man ^{[1
]}

Lohani, Anup ^{[1
]}

Mhaisalkar, Subodh G. ^{[1
]}

Kasim, Johnson ^{[3
]}

Shen, Zexiang ^{[3
]}

Ho, Xinning ^{[4
]}

Rogers, John A. ^{[4
]}

Li, Lain-Jong ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 637819, Singapore

[2] Nanjing Univ Posts & Telecommun, Inst Adv Mat, Nanjing 210046, Peoples R China

[3] Nanyang Technol Univ, Sch Phys & Math Sci, Singapore 637371, Singapore

[4] Univ Illinois, Dept Chem, Dept Mat Sci & Engn, Urbana, IL 61801 USA

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 12期

关键词：

D O I：

10.1002/adma.200702798

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A dramatic sensitivity enhancement in electrical detection of DNA hybridization using single-walled carbon nanotube networked field effect transistors (SNFETs) via introducing reporter DNA-Au nanoparticle (AuNP) conjugates in the hybridization step is reported. The amplified change in drain current allows to reliably determine the DNA concentration down to similar to 100 fM.

引用

页码：2389 / +

页数：6

共 17 条

[1] Flexible nanotube electronics
Bradley, K
Gabriel, JCP
Grüner, G
[J]. NANO LETTERS, 2003, 3 (10) : 1353 - 1355
[2] Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection
Cao, YWC
Jin, RC
Mirkin, CA
[J]. SCIENCE, 2002, 297 (5586) : 1536 - 1540
[3] An investigation of the mechanisms of electronic sensing of protein adsorption on carbon nanotube devices
Chen, RJ
Choi, HC
Bangsaruntip, S
Yenilmez, E
Tang, XW
Wang, Q
Chang, YL
Dai, HJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (05) : 1563 - 1568
[4] Controlling energy-level alignments at carbon nanotube/Au contacts
Cui, XD
Freitag, M
Martel, R
Brus, L
Avouris, P
[J]. NANO LETTERS, 2003, 3 (06) : 783 - 787
[5] DNA sensing by field-effect transistors based on networks of carbon nanotubes
Gui, Ee Ling
Li, Lain-Jong
Zhang, Keke
Xu, Yangping
Dong, Xiaochen
Ho, Xinning
Lee, Pooi See
Kasim, Johnson
Shen, Z. X.
Rogers, John A.
Mhaisalkar, S. G.
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (46) : 14427 - 14432
[6] Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors
Gui, Ee-Ling
Li, Lain-Jong
Lee, P. S.
Lohani, Anup
Mhaisalkar, S. G.
Cao, Qing
Kang, Seong Jun
Rogers, John A.
Tansil, N. C.
Gao, Zhiqiang
[J]. APPLIED PHYSICS LETTERS, 2006, 89 (23)
[7] Femtomolar electrochemical detection of DNA targets using metal sulfide nanoparticles
Hansen, JA
Mukhopadhyay, R
Hansen, JO
Gothelf, KV
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (12) : 3860 - 3861
[8] Nanotransfer printing by use of noncovalent surface forces: Applications to thin-film transistors that use single-walled carbon nanotube networks and semiconducting polymers
Hur, SH
Khang, DY
Kocabas, C
Rogers, JA
[J]. APPLIED PHYSICS LETTERS, 2004, 85 (23) : 5730 - 5732
[9] Effects of coadsorption on the conductance of molecular wires
Lang, ND
Avouris, P
[J]. NANO LETTERS, 2002, 2 (10) : 1047 - 1050
[10] Tuning of electrical characteristics in networked carbon nanotube field-effect transistors using thiolated molecules
Lee, Chun Wei
Zhang, Keke
Tantang, H.
Lohani, Anup
Mhaisalkar, S. G.
Li, Lain-Jong
Nagahiro, T.
Tamada, K.
Chen, Y.
[J]. APPLIED PHYSICS LETTERS, 2007, 91 (10)

← 1 2 →