The chlorhexidine:: β-cyclodextrin inclusion compound:: Preparation, characterization and microbiological evaluation

被引：66

作者：

Cortés, ME

Sinisterra, RD

Avila-Campos, MJ

Tortamano, N

Rocha, RG

机构：

[1] Univ Fed Minas Gerais, Fac Odontol, Dept Odontol Restauradora, BR-31270901 Belo Horizonte, MG, Brazil

[2] UFMG, ICEX, Dept Quim, Belo Horizonte, MG, Brazil

[3] ICB, Dept Microbiol, Sao Paulo, Brazil

[4] Univ Sao Paulo, Fac Odontol, BR-05508 Sao Paulo, Brazil

来源：

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2001年 / 40卷 / 04期

关键词：

chlorhexidine; beta-cyclodextrin; minimum inhibitory concentration;

D O I：

10.1023/A:1012788432106

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The 1 : 2 chlorhexidine : beta -cyclodextrin (Cx : beta CD) complex was prepared and characterised using X-ray crystallography, infrared spectroscopy, thermal analysis and nuclear magnetic resonance. The minimum inhibitory concentration (MIC50) of the chlorhexidine : beta -cyclodextrin inclusion compound against Streptococcus mutans, Eubacterium Lentum, Fusobacterium nucleatum, Bacteroides fragilis and Actinomices actinomycetemcomitans was determined. The Cx : beta CD inclusion compound inhibited the bacterial growth at a low concentration.

引用

页码：297 / 302

页数：6

共 18 条

[1] CHLORHEXIDINE COMPARED WITH OTHER LOCALLY DELIVERED ANTIMICROBIALS - A SHORT REVIEW [J].