Mechanisms of thyroid hormone action

被引：879

作者：

Brent, Gregory A. ^{[1
,2
,3
]}

机构：

[1] VA Greater Los Angeles Healthcare Syst, Dept Med, Los Angeles, CA 90073 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2012年 / 122卷 / 09期

关键词：

STEROID-RECEPTOR COACTIVATOR-1; MONOCARBOXYLATE TRANSPORTER 8; RETINOIC ACID RECEPTORS; CELL-SURFACE RECEPTOR; GENE-EXPRESSION; TYPE-3; DEIODINASE; RESPONSE ELEMENT; PROTEIN-KINASE; IN-VIVO; TR-BETA;

D O I：

10.1172/JCI60047

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Our understanding of thyroid hormone action has been substantially altered by recent clinical observations of thyroid signaling defects in syndromes of hormone resistance and in a broad range of conditions, including profound mental retardation, obesity, metabolic disorders, and a number of cancers. The mechanism of thyroid hormone action has been informed by these clinical observations as well as by animal models and has influenced the way we view the role of local ligand availability; tissue and cell-specific thyroid hormone transporters, corepressors, and coactivators; thyroid hormone receptor (TR) isoform-specific action; and cross-talk in metabolic regulation and neural development. In some cases, our new understanding has already been translated into therapeutic strategies, especially for treating hyperlipidemia and obesity, and other drugs are in development to treat cardiac disease and cancer and to improve cognitive function.

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页码：3035 / 3043

页数：9

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