Nitric oxide signaling in the brain: A new target for inhaled nitric oxide?

被引：36

作者：

Charriaut-Marlangue, Christiane ^{[1
,2
]}

Bonnin, Philippe ^{[3
,4
]}

Pham, Hoa ^{[1
]}

Loron, Gauthier ^{[1
]}

Leger, Pierre-Louis ^{[1
,2
,5
]}

Gressens, Pierre ^{[1
,2
]}

Renolleau, Sylvain ^{[2
,5
]}

Baud, Olivier ^{[1
,2
,6
]}

机构：

[1] Paris Diderot Univ, Sorbonne Paris Cite, INSERM, U676, Paris, France

[2] PremUP Fdn, Paris, France

[3] Paris Diderot Univ, Sorbonne Paris Cite, Publ Hosp Network Paris, Lariboisiere Hosp, Paris, France

[4] Paris Diderot Univ, Sorbonne Paris Cite, Natl Inst Hlth & Med Res, Paris, France

[5] Univ Paris 06, Publ Hosp Network Paris, Armand Trousseau Hosp, Pediat Resuscitat Serv, F-75252 Paris 05, France

[6] Paris Diderot Univ, Sorbonne Paris Cite, Publ Hosp Network Paris, Neonatal Resuscitat Serv, Paris, France

来源：

ANNALS OF NEUROLOGY | 2013年 / 73卷 / 04期

关键词：

CEREBRAL-BLOOD-FLOW; RESPIRATORY-DISTRESS-SYNDROME; REDUCES INFARCT VOLUME; ACUTE ISCHEMIC-STROKE; HYPOXIA-ISCHEMIA; L-NAME; PREMATURE-INFANTS; PLATELET-AGGREGATION; SYNTHASE INHIBITORS; FOREBRAIN ISCHEMIA;

D O I：

10.1002/ana.23842

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Nitric oxide (NO) is a powerful vasodilator, involved in both physiological functions and pathophysiological alterations of various regulatory processes, for example, the maintenance of vascular tone and inflammation. The recently demonstrated impact of exogenous NO on the central nervous system extends its role under normal and pathological conditions. At times neuroprotective, at times neurotoxic, NO is capable of different effects depending upon the extent of cerebral damage, the cellular redox state, and the spatiotemporal coordinates and concentration at which it is synthesized. This review provides new insights into the short- and long-term effects of endogenous and exogenous NO in brain injury. ANN NEUROL 2013;73:442-448

引用

页码：442 / 448

页数：7

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