Perspectives on the chemical etiology of breast cancer

被引：60

作者：

DeBruin, LS ^{[1
]}

Josephy, PD ^{[1
]}

机构：

[1] Univ Guelph, Dept Chem & Biochem, Guelph Waterloo Ctr Grad Work Chem, GWC, Guelph, ON N1G 2W1, Canada

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 2002年 / 110卷

关键词：

heterocyclic amines; mammary carcinogens; PhIP; risk factors;

D O I：

10.1289/ehp.02110s1119

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Multiple factors, known and unknown, contribute to human breast cancer. Hereditary, hormonal, and reproductive factors are associated with risk of breast cancer. Environmental agents, including chemical carcinogens, are modifiable risk factors to which over 70% of breast cancers have been attributed. Polymorphisms of drug-metabolizing enzymes may influence risk of breast cancer from environmental chemicals, dietary agents, and endogenous steroids. The environmental factors discussed in this review include pollutants, occupational exposures, tobacco smoke, alcohol, and diet. Aromatic amines are discussed as potential mammary carcinogens, with a focus on heterocyclic amine food pyrolysis products. These compounds axe excreted into the urine after consumption of meals containing cooked meats and have recently been detected in the breast milk of lactating women.

引用

页码：119 / 128

页数：10

共 194 条

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