A one step synthesis of thiazolines from esters

被引：47

作者：

Busacca, CA

Dong, Y

Spinelli, EM

机构：

[1] Dept. of Process Research, Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT 06877-0368

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 17期

关键词：

D O I：

10.1016/0040-4039(96)00451-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Condensation of the triisobutylaluminum complex of cysteamine HCl with a variety of carboxylic esters furnishes thiazolines in one step. This new method has been applied to chiral alpha-aminoesters to give alpha-amino thiazolines of high optical purity, yet N-benzyl protection of the amine is required (C) 1996 Elsevier Science Ltd

引用

页码：2935 / 2938

页数：4

共 12 条

[1]

BUSACCA CA, 1995, J MED CHEM, V38, P2551

[2]

GABRIEL S, 1916, CHEM BER, P1110

[3]

GORDON AJ, 1972, CHEM COMPANION, P379

[4] ONE-STEP CONVERSIONS OF ESTERS TO 2-IMIDAZOLINES, BENZIMIDAZOLES, AND BENZOTHIAZOLES BY ALUMINUM ORGANIC-REAGENTS [J].