Hyaluronectin blocks the stimulatory effect of hyaluronan-derived fragments on endothelial cells during angiogenesis in vitro

被引：45

作者：

Trochon, V

MabilatPragnon, C

Bertrand, P

Legrand, Y

Soria, J

Soria, C

Delpech, B

Lu, H

机构：

[1] HOP ST LOUIS, INST HEMATOL, INSERM, U353, F-75475 PARIS 10, FRANCE

[2] CTR HENRI BECQUEREL, ONCOL MOL LAB, F-76038 ROUEN, FRANCE

[3] FAC MED & PHARM ROUEN, LAB DIFEMA, ROUEN, FRANCE

[4] HOP HOTEL DIEU, LAB ST MARIE, PARIS, FRANCE

来源：

FEBS LETTERS | 1997年 / 418卷 / 1-2期

基金：

澳大利亚研究理事会;

关键词：

angiogenesis; endothelial cell; hyaluronectin; hyaluronan; hyaluronidase;

D O I：

10.1016/S0014-5793(97)01337-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hyaluronic acid (HA) is a glycosaminoglycan of the extracellular matrix, Its fragmentation by the hyaluronidase, secreted by tumor cells, facilitates tumor invasion and the HA degradation products generated stimulate angiogenesis, We report here that the HA-binding protein hyaluronectin (HN) inhibits the stimulatory effect of HA-derived fragments on the proliferation and migration of endothelial cells in vitro, and hampers the organization of endothelial cells into capillary-like structures, Since HN strongly inhibits endothelial cell adhesion to immobilized HA, it is postulated that HN acts by impairing the binding to endothelial cells of HA fragments generated by hyaluronidase, thereby neutralizing the effect of HA degradation products on angiogenesis. Our results reveal a new mechanism by which the angiogenesis induced by HA fragments is modulated by HN. (C) 1997 Federation of European Biochemical Societies.

引用

页码：6 / 10

页数：5

共 22 条

[1] INTERACTION OF HYALURONECTIN WITH HYALURONIC-ACID OLIGOSACCHARIDES [J].