pADPRT-2:: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans

被引：56

作者：

Berghammer, H ^{[1
]}

Ebner, M ^{[1
]}

Marksteiner, R ^{[1
]}

Auer, B ^{[1
]}

机构：

[1] Univ Innsbruck, Inst Biochem, A-6020 Innsbruck, Austria

来源：

FEBS LETTERS | 1999年 / 449卷 / 2-3期

基金：

奥地利科学基金会;

关键词：

poly(ADP-ribosyl)ation; polymerizing(ADP-ribosyl)transferase negative mouse; genomic organization; activity gel analysis; sequence comparison;

D O I：

10.1016/S0014-5793(99)00448-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Until recently, poly(ADP-ribosyl)ation was supposed to he confined only to polymerizing(ADP-ribosyl)transferase/(ADP-ribose)polymerase (E.C. 2.4.2.30), Here, we present novel polymerizing(ADP-ribosyl)transferase homologues from mouse and man that lack all of the N-terminal DSA binding and BRCA1 C-terminus domains and will be designated polymerizing(ADP-ribosyl)transferase-2 as distinguished from the classical polymerizing(ADP-ribosyl)transferase (polymerizing(ADP-ribosyl)transferase-1). The murine polymerizing(ADP-ribosyl)transferase-2 gene shares three identical intron positions with its Caenorhabditis elegans (EMBL nucleotide sequence database Z47075) and one with the Arabidopsis thaliana homologue ('APP', GenBank database AF069298), Expression of the murine polymerizing(ADP-ribosyl)transferase-2 gene was elevated in spleen, thymus and testis and the corresponding poly(ADP-ribosyl)ation activity might account for most of the residual poly(ADP-ribosyl)ation observed in polymerizing(ADP-ribosyl)transferase-1(-/-) mice. (C) 1999 Federation of European Biochemical Societies.

引用

页码：259 / 263

页数：5

共 24 条

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