Embryonic wound healing: A primer for engineering novel therapies for tissue repair

被引：21

作者：

Degen, Katherine E. ^{[2
]}

Gourdie, Robert G. ^{[1
,2
]}

机构：

[1] Virginia Tech, Caril Res Inst, Roanoke, VA 24015 USA

[2] Virginia Tech, Sch Biomed Engn Sci, Blacksburg, VA USA

来源：

BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS | 2012年 / 96卷 / 03期

关键词：

tissue engineering; embryonic wound healing; CONNEXIN43; CARBOXYL-TERMINUS; HEPATOCYTE GROWTH-FACTOR; MUSCLE ACTIN EXPRESSION; STEM-CELL THERAPY; SCAR FORMATION; INFLAMMATORY RESPONSE; EXTRACELLULAR-MATRIX; TRANSFORMING GROWTH-FACTOR-BETA-1; EPIDERMAL-KERATINOCYTES; DERMAL FIBROBLASTS;

D O I：

10.1002/bdrc.21019

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Scar is the default tissue repair used by the body in response to most injuriesa response that occurs in wounds ranging in seriousness from minor skin cuts to complete severance of the spinal cord. By contrast, before the third trimester of pregnancy embryonic mammals tend to heal without scarring due to a variety of mechanisms and factors that are uniquely in operation during development in utero. The goal of tissue engineering is to develop safe and clinically effective biological substitutes that restore, maintain, or improve tissue function in patients. This review provides a comparative overview of wound healing during development and maturation and seeks to provide a perspective on just how much the embryo may be able teach us in the engineering of new therapies for tissue repair. Birth Defects Research (Part C) 96:258270, 2012. (C) 2012 Wiley Periodicals, Inc.

引用

页码：258 / 270

页数：13

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