Major gene effects on apolipoprotein B concentrations in families of adolescents - Results from a community-based study in Taiwan

被引:5
作者
Chien, KL
Chen, WJ
Hsu, HC
Su, TC
Chen, MF
Lee, YT
机构
[1] Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol, Taipei 100, Taiwan
[2] Natl Taiwan Univ, Coll Publ Hlth, Inst Prevent Med, Taipei, Taiwan
[3] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan
[4] Natl Taiwan Univ Hosp, Dept Psychiat, Taipei, Taiwan
关键词
apolipoprotein B; heritability; major genes; community study;
D O I
10.1016/j.cca.2005.08.025
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 [基础医学];
摘要
Background: Apolipoprotein (Apo) B is considered as a risk factor for atherosclerosis. Previous reports of segregation analyses on the mode of inheritance of Apo B were inconsistent because of heterogeneity in study population or elderly adult diseased probands. We performed complex segregation analysis of Apo B levels in the families of adolescents, systematically ascertained from junior high school students in a rural community in Taiwan. Results: There is a sex-specific influence in the variation of apo B levels. The mother-daughter (0.216), sister-sister (0.181), sister-brother (0.179) correlations were higher than father-son (0.206), brother-brother (0.002) or cross-sex correlations for the variation in Apo B levels. By the variance component model, the heritability estimate was 26.3 +/- 6.7% (P <.0001) in Apo B levels. Commingling analysis indicated that a 2-component distribution was needed to account for Apo B variation. Segregation analysis using regressive models revealed that the best-fit model of Apo B was the model of major gene effect plus familial correlation. The gene frequency controlling high Apo B was 0.17, and 3 means of genotypes were 56.3, 54,2, and 117.2 mg/dl. Conclusion: Variations of Apo B levels in the normal range among adolescent families are controlled by major gene, and further identification of this gene locus will be mandatory. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:194 / 199
页数:6
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