Poly(ethylenimine) and its role in gene delivery

被引：1066

作者：

Godbey, WT

Wu, KK

Mikos, AG

机构：

[1] Rice Univ, Dept Bioengn, Houston, TX 77251 USA

[2] Rice Univ, Dept Biochem & Cell Biol, Houston, TX 77251 USA

[3] Univ Texas, Hlth Sci Ctr, Div Hematol, Houston, TX 77030 USA

[4] Univ Texas, Hlth Sci Ctr, Vasc Biol Res Ctr, Houston, TX 77030 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 1999年 / 60卷 / 2-3期

关键词：

poly(ethylenimine); PEI; polycation; nonviral gene delivery; transfection; cell trafficking;

D O I：

10.1016/S0168-3659(99)00090-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Since the first published examination of poly(ethylenimine) (PEI) as a gene delivery vehicle, there has been a hurry of research aimed at this polycation and its role in gene therapy. Here we will briefly review PEI chemistry and the characterization of PEI/DNA complexes used for gene delivery. Additionally, we will note various PEI transfection considerations and examine findings involving other polycationic gene delivery vehicles used with cellular targeting ligands. The current state of our knowledge regarding the mechanism of PEI/DNA transfection will also be discussed. Finally, we will survey toxicity issues related to PEI transfection. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：149 / 160

页数：12

共 72 条

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