Role of Extracellular Vesicles in De Novo Mineralization: An Additional Novel Mechanism of Cardiovascular Calcification

被引：117

作者：

New, Sophie E. P. ^{[1
]}

Aikawa, Elena ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Interdisciplinary Cardiovasc Sci, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Excellence Vasc Biol, Boston, MA 02115 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2013年 / 33卷 / 08期

基金：

美国国家卫生研究院;

关键词：

atherosclerosis; calcification; extracellular vesicles; inflammation; macrophages; rupture; valve disease; AORTIC-VALVE CALCIFICATION; SMOOTH-MUSCLE-CELLS; MATRIX VESICLES; VASCULAR CALCIFICATION; ALKALINE-PHOSPHATASE; ATHEROSCLEROTIC CALCIFICATION; ARTERIAL CALCIFICATION; EPIPHYSEAL CARTILAGE; MEMBRANE-VESICLES; BINDING PROTEINS;

D O I：

10.1161/ATVBAHA.112.300128

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Extracellular vesicles are membrane micro/nanovesicles secreted by many cell types into the circulation and the extracellular milieu in physiological and pathological conditions. Evidence suggests that extracellular vesicles, known as matrix vesicles, play a role in the mineralization of skeletal tissue, but emerging ultrastructural and in vitro studies have demonstrated their contribution to cardiovascular calcification as well. Cells involved in the progression of cardiovascular calcification release active vesicles capable of nucleating hydroxyapatite on their membranes. This review discusses the role of extracellular vesicles in cardiovascular calcification and elaborates on this additional mechanism of calcification as an alternative pathway to the currently accepted mechanism of biomineralization via osteogenic differentiation.

引用

页码：1753 / 1758

页数：6

共 56 条

[1] Vascular calcification - Mechanisms and clinical ramifications [J].