Plasmodium falciparum -: induced channels

被引：24

作者：

Staines, HM

Powell, T

Thomas, SLY

Ellory, JC

机构：

[1] Univ Oxford, Physiol Lab, Oxford OX1 3PT, England

[2] CNRS, Biol Stn, UMR 7127, F-29682 Roscoff, France

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2004年 / 34卷 / 06期

基金：

英国惠康基金;

关键词：

malaria; membrane transport; channel; electrophysiology; erythrocyte;

D O I：

10.1016/j.ijpara.2004.02.007

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

To survive within a red blood cell, the malaria parasite alters dramatically the permeability of the host's plasma membrane (allowing the uptake of essential nutrients and the removal of potentially hazardous metabolites). The pathway(s) responsible for the increased permeability have been proposed as putative chemotherapeutic targets and/or selective routes for antimalarial agents that target the internal parasite. This review covers our current understanding of this parasite-induced phenomenon in Plasmodium falciparum-infected human red blood cells. In particular, recent electrophysiological studies, using the patch-clamp technique, are reviewed. (C) 2004 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

引用

收藏

页码：665 / 673

页数：9

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