Bile acid nuclear receptor FXR and digestive system diseases

被引：322

作者：

Ding, Lili ^{[1
,2
,3
]}

Yang, Li ^{[1
,2
]}

Wang, Zhengtao ^{[1
,2
]}

Huang, Wendong ^{[3
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Shanghai Key Lab Complex Prescript, Inst Chinese Mat Med, Shanghai 201203, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, MOE Key Lab Standardizat Chinese Med, Inst Chinese Mat Med, Shanghai 201203, Peoples R China

[3] City Hope Natl Med Ctr, Beckman Res Inst, Dept Diabet & Metab Dis Res, Duarte, CA 91010 USA

来源：

ACTA PHARMACEUTICA SINICA B | 2015年 / 5卷 / 02期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Bile acids; Farnesoid X receptors; Gastrointestinal tract; Inflammatory bowel disease; Colorectal cancer; Type; 2; diabetes; FARNESOID-X-RECEPTOR; FIBROBLAST-GROWTH-FACTOR; ORGANIC SOLUTE TRANSPORTER; Y GASTRIC BYPASS; COLON-CANCER; SLEEVE GASTRECTOMY; BACTERIAL TRANSLOCATION; TRIGLYCERIDE LEVELS; GLUCOSE-METABOLISM; ADAPTIVE RESPONSE;

D O I：

10.1016/j.apsb.2015.01.004

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Bile acids (BAs) are not only digestive surfactants but also important cell signaling molecules, which stimulate several signaling pathways to regulate some important biological processes. The bile-acid-activated nuclear receptor, farnesoid X receptor (FXR), plays a pivotal role in regulating bile acid, lipid and glucose homeostasis as well as in regulating the inflammatory responses, harrier function and prevention of bacterial manslocation in the intestinal tract. As expected, FXR is involved in the pathophysiology of a wide, range of diseases of gastrointestinal tract, including inflammatory bowel disease, colorectal cancer and type 2 diabetes. In this review, we discuss current knowledge of the roles of FXR in physiology of the digestive system and the related diseases. Better understanding of the roles of FXR in digestive system will accelerate the development of FXR ligands/modulators for the treatment of digestive system diseases. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. All rights reserved

引用

页码：135 / 144

页数：10

共 132 条

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Long-term effects of laparoscopic sleeve gastrectomy, gastric bypass, and adjustable gastric banding on type 2 diabetes [J].