Tubulogenesis from isolated single cells of adult mammalian kidney: Clonal analysis with a recombinant retrovirus

被引:50
作者
Humes, HD
Krauss, JC
Cieslinski, DA
Funke, AJ
机构
[1] UNIV MICHIGAN, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA
[2] VET ADM MED CTR, DEPT INTERNAL MED, ANN ARBOR, MI 48105 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL FLUID AND ELECTROLYTE PHYSIOLOGY | 1996年 / 271卷 / 01期
关键词
progenitor cells; proximal tubule; growth factors; morphogenesis; regeneration;
D O I
10.1152/ajprenal.1996.271.1.F42
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The adult mammalian kidney tubule epithelium exists in a relatively dormant, slowly replicative state but has a large potential for regenerative morphogenesis following severe ischemic or toxic injury. Under selective serum-free growth conditions, which included epidermal growth factor and retinoic acid, a subpopulation of renal proximal tubule cells isolated from adult rabbit kidney were grown in cell culture. These cells possessed two important characteristics: 1) an ability to differentiate morphogenically into tubule structures when grown in three-dimensional collagen gels and 2) a high capacity for self-renewal, since cell Lineage analysis with a recombinant retrovirus demonstrated that in vitro tubulogenesis arose from clonal expansion of a single cell. Thus individual cells in the adult kidney have retained the ability for kidney tubulogenesis in vitro.
引用
收藏
页码:F42 / F49
页数:8
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