Regulation of life-span by germ-line stem cells in Caenorhabditis elegans

被引：376

作者：

Arantes-Oliveira, N ^{[1
]}

Apfeld, J ^{[1
]}

Dillin, A ^{[1
]}

Kenyon, C ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

来源：

SCIENCE | 2002年 / 295卷 / 5554期

关键词：

D O I：

10.1126/science.1065768

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The germ line of the nematode Caenorhabditis elegans influences life-span; when the germ-line precursor cells are removed, life-span is increased dramatically. We find that neither sperm, nor oocytes, nor meiotic precursor cells are responsible for this effect. Rather life-span is influenced by the proliferating germ-line stem cells. These cells, as well as a downstream transcriptional regulator, act in the adult to influence aging, indicating that the aging process remains plastic during adulthood. We propose that the germ-line stem cells affect life-span by influencing the production of, or the response to, a steroid hormone that promotes longevity.

引用

页码：502 / 505

页数：4

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