Growing up on the streets: why B-cell development differs from T-cell development

被引：28

作者：

Townsend, SE ^{[1
]}

Weintraub, BC ^{[1
]}

Goodnow, CC ^{[1
]}

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, Med Genome Ctr, Australian Canc Res Fdn,Genet Lab, Canberra, ACT 2601, Australia

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 05期

关键词：

D O I：

10.1016/S0167-5699(98)01440-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B-cell development differs significantly from T-cell development in that negative selection of autoreactive B cells can occur in the same microenvironment in which productive immune responses begin. Here, Sarah Townsend and colleagues discuss how this 'growing up on the streets' might provide a mechanism that fills holes in the B-cell repertoire, much as major histocompatibility complex polymorphism fills holes in the T-cell repertoire.

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页码：217 / 220

页数：4

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