Leptin mediates a proliferative response in human MCF7 breast cancer cells

被引：256

作者：

Dieudonne, MN ^{[1
]}

Machinal-Quelin, F ^{[1
]}

Serazin-Leroy, V ^{[1
]}

Leneveu, MC ^{[1
]}

Pecquery, R ^{[1
]}

Giudicelli, Y ^{[1
]}

机构：

[1] Univ Paris 05, Ctr Hosp Poissy, Fac Med Paris Ouest, Serv Biochim & Biol Mol, F-78303 Poissy, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2002年 / 293卷 / 01期

关键词：

leptin; leptin receptors; MCF-7; proliferation; signal transduction;

D O I：

10.1016/S0006-291X(02)00205-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity is a risk factor of breast cancers. As leptin, a hormone mainly secreted by white adipocytes, elicits proliferative effects in some cell types. we tested the hypothesis that leptin could influence human breast cancer MCF-7 cell growth. Here we show that MCF-7 cells express leptin receptors and respond to human recombinant leptin by STAT3 and p42/p44 MAPkinase activations and by increased proliferation. These findings suggest that leptin could act in vivo as a paracrine/endocrine growth factor towards mammary epithelial cells thus contributing to explain why obesity is a risk factor of developing breast cancers. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

页码：622 / 628

页数：7

共 36 条

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