Curcumin Enhances Cytotoxic Effects of Bortezomib in Human Multiple Myeloma H929 Cells: Potential Roles of NF-κB/JNK

被引：34

作者：

Bai, Qing-Xian ^{[1
]}

Zhang, Xiao-Yan ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Dept Hematol, State Ctr Bone Marrow Transplantat, Xijing Hosp, Xian 710032, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2012年 / 13卷 / 04期

基金：

中国国家自然科学基金;

关键词：

curcumin; PS-341; multiple myeloma; NF-kappa B; JNK; PROTEASOME INHIBITORS; CANCER CELLS; SUPPRESSES; APOPTOSIS; FLAVOPIRIDOL; ACTIVATION; LYMPHOMA;

D O I：

10.3390/ijms13044831

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Combined curcumin and PS-341 treatment has been reported to enhance cytotoxicity and minimize adverse effects through ERK and p38MAPK mechanisms in human multiple myeloma cells. However, whether JNK plays similar role in this process remains unclear. In the present study, we found combined treatment altered NF-kappa B p65 expressions and distributions in multiple myeloma H929 cells. Western blot analysis showed combined treatment inactivated NF-kappa B while activated JNK signaling. Pre-treatment with JNK inhibitor SP600125 could attenuate NF-kappa B inactivation and restored H929 cells' survival. These results suggested that curcumin might enhance the cytotoxicity of PS-341 by interacting with NF-kappa B, at least in part, through JNK mechanism.

引用

收藏

页码：4831 / 4838

页数：8

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