Mitochondrial DNA 4977 bp deletion and OH8dG levels correlate in the brain of aged subjects but not Alzheimer's disease patients

被引：67

作者：

Lezza, AMS

Mecocci, P

Cormio, A

Beal, MF

Cherubini, A

Cantatore, P

Senin, U

Gadaleta, MN

机构：

[1] Univ Bari, Dept Biochem & Mol Biol, I-70125 Bari, Italy

[2] Univ Perugia, Dept Gerontol & Geriatr, I-06122 Perugia, Italy

[3] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Boston, MA 02114 USA

来源：

FASEB JOURNAL | 1999年 / 13卷 / 09期

关键词：

aging; mtDNA; deletions; mtDNA oxidative damage; neurodegenerative disease;

D O I：

10.1096/fasebj.13.9.1083

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The levels of mitochondrial DNA 4977 bp deletion (mtDNA(4977)) and mitochondrial DNA 8'-hydroxy-2'-deoxyguanosine (OH(8)dG) were determined in the same samples from two brain areas of healthy subjects and Alzheimer's disease (AD) patients, A positive correlation between the age-related increases of mtDNA(4977) and of OH(8)dG levels was found in the brain of healthy individuals. On the contrary, in both brain areas of AD patients, mtDNA(4977) levels were very low in the presence of high OH(8)dG amounts. These results might be explained assuming that the increase of OH(8)dG above a threshold level, as in AD patients, implies consequences for mtDNA replication and neuronal cell survival.

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页码：1083 / 1088

页数：6

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