Maintaining success, reducing treatment burden, focusing on survivorship: highlights from the third European consensus conference on diagnosis and treatment of germ-cell cancer

被引：219

作者：

Beyer, J. ^{[1
]}

Albers, P. ^{[2
]}

Altena, R. ^{[3
]}

Aparicio, J. ^{[4
]}

Bokemeyer, C. ^{[5
]}

Busch, J. ^{[6
]}

Cathomas, R. ^{[7
]}

Cavallin-Stahl, E. ^{[8
]}

Clarke, N. W. ^{[9
]}

Classen, J. ^{[10
]}

Cohn-Cedermark, G. ^{[11
,12
]}

Dahl, A. A. ^{[13
,14
]}

Daugaard, G. ^{[15
]}

De Giorgi, U. ^{[16
]}

De Santis, M. ^{[17
]}

De Wit, M. ^{[18
]}

De Wit, R. ^{[19
]}

Dieckmann, K. P. ^{[20
]}

Fenner, M. ^{[21
]}

Fizazi, K. ^{[22
]}

Flechon, A. ^{[23
]}

Fossa, S. D. ^{[13
,14
]}

Germa Lluch, J. R. ^{[24
]}

Gietema, J. A. ^{[3
]}

Gillessen, S. ^{[25
]}

Giwercman, A. ^{[26
]}

Hartmann, J. T. ^{[27
]}

Heidenreich, A. ^{[28
]}

Hentrich, M. ^{[29
]}

Honecker, F. ^{[5
]}

Horwich, A. ^{[30
]}

Huddart, R. A. ^{[31
]}

Kliesch, S. ^{[32
]}

Kollmannsberger, C. ^{[33
]}

Krege, S. ^{[34
]}

Laguna, M. P. ^{[35
]}

Looijenga, L. H. J. ^{[36
]}

Lorch, A. ^{[2
]}

Lotz, J. P. ^{[37
]}

Mayer, F. ^{[38
]}

Necchi, A. ^{[39
]}

Nicolai, N. ^{[40
]}

Nuver, J. ^{[3
]}

Oechsle, K. ^{[5
]}

Oldenburg, J. ^{[41
]}

Oosterhuis, J. W. ^{[36
]}

Powles, T. ^{[42
]}

Rajpert-De Meyts, E. ^{[43
]}

Rick, O. ^{[44
]}

Rosti, G. ^{[45
]}

机构：

[1] Vivantes Klinikum Urban, Dept Hematol & Oncol, D-10967 Berlin, Germany

[2] Univ Hosp, Dept Urol, Dusseldorf, Germany

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Med Oncol, NL-9713 AV Groningen, Netherlands

[4] Univ Hosp La Fe, Dept Med Oncol, Valencia, Spain

[5] BMT & Pulmonol Univ Hosp, Dept Med Oncol, Hamburg, Germany

[6] Charite, Dept Urol, Berlin, Germany

[7] Kantonsspital Graubunden, Dept Internal Med, Graubunden, Switzerland

[8] Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden

[9] Christie Hosp, Dept Urol, Manchester, Lancs, England

[10] St Vincentius Hosp, Dept Radiat Oncol, Karlsruhe, Germany

[11] Karolinska Inst, Dept Oncol, Stockholm, Sweden

[12] Univ Hosp, Stockholm, Sweden

[13] Norwegian Radium Hosp, Dept Onocol, Natl Resource Ctr Late Effects, Oslo, Norway

[14] Univ Oslo, Oslo, Norway

[15] Rigshosp, Dept Oncol, DK-2100 Copenhagen, Denmark

[16] IRCCS Ist Sci Romagnolo Studio & Cura Tumori IRST, Dept Oncol, Meldola, Italy

[17] LBI ACR VIEnna, ACR ITR VIEnna, Kaiser Franz Josef Spital, Dept Med 3, Vienna, Austria

[18] Vivantes Klinikum Neukolln, Dept Hematol & Oncol, Berlin, Germany

[19] Erasmus Univ, Dept Med Oncol, Rotterdam, Netherlands

[20] Albertinen Hosp, Dept Urol, Hamburg, Germany

[21] Hannover Med Sch, Dept Hematol & Oncol, D-30623 Hannover, Germany

[22] Inst Gustave Roussy, Dept Med, Villejuif, France

[23] Ctr Leon Berard, Dept Med Oncol, F-69373 Lyon, France

[24] Inst Catala Oncol, IDIBELL, Dept Med Oncol, Barcelona, Spain

[25] Kantonsspital St Gallen, Dept Oncol, St Gallen, Switzerland

[26] Skane Univ Hosp, Reprod Med Ctr, Malmo, Sweden

[27] Univ Hosp Schleswig Holstein, Dept Med Oncol, Kiel, Germany

[28] Univ Hosp, Dept Urol, Aachen, Germany

[29] Harlaching Hosp, Dept Hematol & Oncol, Munich, Germany

[30] Royal Marsden Hosp, Dept Radiotherapy, London SW3 6JJ, England

[31] Royal Marsden Hosp, Dept Radiotherapy, Inst Canc Res, London SW3 6JJ, England

[32] Univ Hosp, Ctr Reprod Med & Androl, Munster, Germany

[33] Univ British Columbia, Div Med Oncol, Vancouver, BC V5Z 1M9, Canada

[34] Hosp Maria Hilf, Dept Urol, Krefeld, Germany

[35] Univ Amsterdam, Acad Med Ctr, Dept Urol, NL-1105 AZ Amsterdam, Netherlands

[36] Erasmus MC, Dept Pathol, Rotterdam, Netherlands

[37] Hop Tenon, Dept Clin Oncol, F-75970 Paris, France

[38] Univ Tubingen Hosp, Dept Hematol & Oncol, Tubingen, Germany

[39] Fdn IRCCS, Ist Nazl Tumori, Med Oncol Unit, Dept Med Oncol, Milan, Italy

[40] Fdn IRCCS, Ist Nazl Tumori, Urol Unit, Dept Surg, Milan, Italy

[41] Oslo Univ Hosp, Norwegian Radium Hosp, Clin Canc Res, Oslo, Norway

[42] St Bartholomews Hosp, Dept Med Oncol, London, England

[43] Rigshosp, Dept Growth & Reprod, DK-2100 Copenhagen, Denmark

[44] Hosp Reinhardshohe, Dept Med, Bad Wildungen, Germany

[45] Osped Civile Ca Foncello, Dept Med Oncol, Treviso, Italy

[46] Univ Hosp, Dept Urol, Ulm, Germany

[47] Paracelsus Med Univ Hosp, Dept Radiotherapy & Radiat Oncol, Salzburg, Austria

[48] Royal Marsden Hosp, Dept Diagnost Radiol, London SW3 6JJ, England

[49] Univ Tubingen Hosp, Dept Radiat Oncol, Tubingen, Germany

[50] St Olavs Hosp, Dept Oncol, Trondheim, Norway

来源：

ANNALS OF ONCOLOGY | 2013年 / 24卷 / 04期

关键词：

consensus conference; diagnosis; germ-cell cancer; late toxic effects; long-term follow-up; treatment; LYMPH-NODE DISSECTION; HIGH-DOSE CHEMOTHERAPY; RISK-ADAPTED TREATMENT; RANDOMIZED PHASE-III; LONG-TERM SURVIVORS; STAGE-I SEMINOMA; POSITRON-EMISSION-TOMOGRAPHY; TESTICULAR CANCER; FOLLOW-UP; COMPUTED-TOMOGRAPHY;

D O I：

10.1093/annonc/mds579

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In November 2011, the Third European Consensus Conference on Diagnosis and Treatment of Germ-Cell Cancer (GCC) was held in Berlin, Germany. This third conference followed similar meetings in 2003 (Essen, Germany) and 2006 (Amsterdam, The Netherlands) [Schmoll H-J, Souchon R, Krege S et al. European consensus on diagnosis and treatment of germ-cell cancer: a report of the European Germ-Cell Cancer Consensus Group (EGCCCG). Ann Oncol 2004; 15: 1377-1399; Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ-cell cancer: a report of the second meeting of the European Germ-Cell Cancer Consensus group (EGCCCG): part I. Eur Urol 2008; 53: 478-496; Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ-cell cancer: a report of the second meeting of the European Germ-Cell Cancer Consensus group (EGCCCG): part II. Eur Urol 2008; 53: 497-513]. A panel of 56 of 60 invited GCC experts from all across Europe discussed all aspects on diagnosis and treatment of GCC, with a particular focus on acute and late toxic effects as well as on survivorship issues. The panel consisted of oncologists, urologic surgeons, radiooncologists, pathologists and basic scientists, who are all actively involved in care of GCC patients. Panelists were chosen based on the publication activity in recent years. Before the meeting, panelists were asked to review the literature published since 2006 in 20 major areas concerning all aspects of diagnosis, treatment and follow-up of GCC patients, and to prepare an updated version of the previous recommendations to be discussed at the conference. In addition, similar to 50 E-vote questions were drafted and presented at the conference to address the most controversial areas for a poll of expert opinions. Here, we present the main recommendations and controversies of this meeting. The votes of the panelists are added as online supplements.

引用

页码：878 / 888

页数：11

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