Action in the axon: generation and transport of signaling endosomes

被引：111

作者：

Cosker, Katharina E. ^{[1
,2
]}

Courchesne, Stephanie L. ^{[1
,2
]}

Segal, Rosalind A. ^{[1
,2
]}

机构：

[1] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2008年 / 18卷 / 03期

关键词：

D O I：

10.1016/j.conb.2008.08.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurons extend axonal processes over long distances, necessitating efficient transport mechanisms to convey target-derived neurotrophic survival signals from remote distal axons to cell bodies. Retrograde transport, powered by dynein motors, supplies cell bodies with survival signals in the form of 'signaling endosomes'. In this review, we will discuss new advances in our understanding of the motor proteins that bind to and move signaling components in a retrograde direction and discuss mechanisms that might specify distinct neuronal responses to spatially restricted neurotrophin signals. Disruption of retrograde transport leads to a variety of neurodegenerative diseases, highlighting the role of retrograde transport of signaling endosomes for axonal maintenance and the importance of efficient transport for neuronal survival and function.

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页码：270 / 275

页数：6

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