Towards the identification of novel platelet receptors: Comparing RNA and proteome approaches

Over the past few years, the new technologies of transcriptomics and proteomics have been applied to platelet research. Whole-genome profiling of the transcriptome using microarray hybridization can be performed with less time and effort compared to proteome investigation. On the other hand, the significance of RNA data may be limited with regard to actual protein expression. This review compares published platelet transcriptome and proteome data in order to identify the number of discrepancies between the two molecular profiles. With a focus on membrane proteins, we wanted to know whether transcriptomic and proteomic studies may contribute to identifying novel platelet proteins.