Contrast agents for magnetic resonance imaging synthesized with ring-opening metathesis polymerization

被引：44

作者：

Allen, Matthew J.

Raines, Ronald T.

Kiessling, Laura L. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 20期

关键词：

D O I：

10.1021/ja061383p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A monomer for ring-opening metathesis polymerization (ROMP) has been developed that also functions as a portion of a GdIII chelating moiety for a magnetic resonance imaging contrast agent. An increase in per GdIII relaxivity was shown upon transition from monomer to polymer. Additionally, extremely large molecular relaxivities were achieved through incorporation of multiple GdIII ions per polymer. The nature of ROMP-derived polymers allows for functionalization of the monomer units and termini through orthogonal chemistry. This strategy is the basis for a new class of highly sensitive, targeted imaging agents. Copyright © 2006 American Chemical Society.

引用

页码：6534 / 6535

页数：2

共 22 条

[1] Gd(III)-based contrast agents for MRI [J].