Differentiating clinical profiles: predicting good responders, poor responders, and hyperresponders

被引:108
作者
Kligman, I [1 ]
Rosenwaks, Z [1 ]
机构
[1] Cornell Univ, Weill Med Coll, Ctr Reprod Med & Infertil, New York, NY 10021 USA
关键词
IVF; ovarian response; ovarian reserve;
D O I
10.1016/S0015-0282(01)02893-X
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To describe the different clinical and laboratory diagnostic methods (basal and dynamic tests) available to identify poor-, good-, and high-responder patients undergoing treatment with in vitro fertilization (IVF). Design: Analytical review. Setting: IVF program. Patients: Women in different age groups undergoing IVF treatment. Intervention(s): Assessment of clinical and laboratory parameters and correlation with outcomes. Main Outcome Measure(s): Response to ovarian stimulation and success of the assisted reproductive technologies (ART). Result(s): Age, basal follicle-stimulating hormone (FSH), estradiol and inhibin-B levels, and dynamic testing serve to predict individual response to ovarian Stimulation for ART. Conclusion(s): Markers of ovarian reserve (day 3 FSH, inhibin B and E-2) are particularly predictive and useful in guiding the choice of the optimal protocol for ART. However, no tests a-re absolutely predictive of a successful outcome. For the younger individual, and for the patient at risk of developing ovarian hyperstimulation syndrome (OHSS), assessment and identification of clinical and laboratory parameters predictive of a high response to ovarian stimulation should guide the clinician in choosing an appropriate stimulation protocol, thus attenuating the risk of OHSS. (Fertil Steril (R) 2001;76:1185-90. (C) 2001 by American Society for Reproductive Medicine.).
引用
收藏
页码:1185 / 1190
页数:6
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